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专家知识库丨学术课件推荐:T细胞抗原识别机制

  • 2026-08-10 17:24:44
专家知识库丨学术课件推荐:T细胞抗原识别机制

医药行业研发周期长、技术壁垒高、信息不对称性显著等特点已是业内共识。优质创新成果长期依赖线下会议和点对点对接，传播受限、效率低下，大量具备临床价值与应用前景的技术方案未能得到充分的产业关注与资本响应。

为此，药未来APP正式推出 “专家知识库” 板块，为医药领域优质企业与个人专家搭建系统化、常态化的成果展示与资源对接平台，助力技术端与资本端、产业端的高效匹配。

专家知识库

学术课件推荐

T细胞抗原识别机制

 王锋 

上海交通大学医学院/上海市免疫学研究所

研究员、课题组长、博士生导师

内容摘要与简介

OVERVIEW

本报告系关于T细胞抗原识别机制的系统性学术阐述，旨在从免疫学基本规律出发，揭示T细胞受体（TCR）如何精准识别病原体或肿瘤来源的抗原肽，从而触发特异性免疫应答。报告指出，TCR是T细胞表面最为关键的特征性分子，其结构与信号转导能力直接决定了机体免疫监视的有效性与疾病转归。通过回顾TCR发现历程中的重要里程碑，报告展示了从早期单克隆抗体鉴定到基因克隆、再到结构与功能解析的完整知识演化路径，强调了基础研究对临床转化的根本驱动作用。

报告详细描述了TCR-CD3复合体的组装模式、ITAM基序在活化信号启动中的核心作用，以及CD4/CD8共受体如何辅助TCR完成对主要组织相容性复合体（MHC）限制性抗原的精准识别。报告进一步结合新冠病毒感染和肿瘤免疫治疗实例，展示了TCR组库动态变化如何反映疾病进程，以及肿瘤新抗原特异性T细胞在清除癌细胞中的决定性作用。这些研究为开发基于TCR的细胞治疗、个性化疫苗及免疫评估工具提供了坚实的理论支撑，亦为后续利用人工智能模型深度挖掘免疫组库数据、实现精准诊疗奠定了生物学根基。该报告贯通了从分子机制到临床转化的完整链条，体现了基础免疫学在现代精准医学中的核心价值。

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版权声明：

本期展示课件已通过药未来平台完成原创版权存证，受平台截屏下载限制。未经授权，禁止任何形式的转载、截屏或传播。

专家介绍

上海交通大学医学院/上海市免疫学研究所研究员、课题组长、博士生导师

国家万人计划青年拔尖人才

上海高校特聘教授(东方学者)

王锋博士长期致力于探索T细胞抗原识别和信号调节机制，以及抗原特异性T细胞在抗肿瘤、感染免疫和自身免疫疾病中的关键作用。以第/ 通讯F者身份在Nature Immunology, Immunity,Science Immunology，PNAS,EMBOJournal等国际知名期刊发表系列研究论文。申请国家/国际发明专利13项(其中6项已授权)，现联合上海交通大学医学院附属三甲医院开展免疫治疗相关临床试验。

入选国家万人计划青年拔尖人才，上海高校特聘教授(东方学者)，上海市青年拔尖人才，上海市浦江人才和曙光学者计划。研究获得包括国家自然科学基金重点项目，免疫力解码专项和国家重点研发计划在内的多个国家和省部级项目资助。担任中国生物医药产业链创新与转化联盟核酸药物分会副主委、免疫治疗药物分会秘书长，中国免疫学会青年工作委员会常委，中国药理学会呼吸药理专委会常委以及上海市免疫学会中医药免疫专委会副主委。

（下滑查看全部简介）

专家知识库

入驻·邀请

“专家知识库”板块现面向以下主体正式开放入驻通道：

在特定治疗领域或技术方向具有深厚积累的个人专家与学者

寻求融资、License-out、联合开发或战略合作的项目负责人

拥有成功转化经验或产业落地案例的资深行业顾问/专家

入驻后，相关展示内容将精准触达平台内的高净值用户群体，包括投资基金、跨国药企（MNC）、大型制药企业BD部门及其他潜在合作伙伴。

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  1. CONNECT:[ UseTime:0.001105s ] mysql:host=127.0.0.1;port=3306;dbname=a_sjds;charset=utf8mb4
  2. SHOW FULL COLUMNS FROM `fenlei` [ RunTime:0.001564s ]
  3. SELECT * FROM `fenlei` WHERE `fid` = 0 [ RunTime:0.000755s ]
  4. SELECT * FROM `fenlei` WHERE `fid` = 63 [ RunTime:0.001275s ]
  5. SHOW FULL COLUMNS FROM `set` [ RunTime:0.001453s ]
  6. SELECT * FROM `set` [ RunTime:0.000695s ]
  7. SHOW FULL COLUMNS FROM `article` [ RunTime:0.001621s ]
  8. SELECT * FROM `article` WHERE `id` = 522840 LIMIT 1 [ RunTime:0.001042s ]
  9. UPDATE `article` SET `lasttime` = 1786436743 WHERE `id` = 522840 [ RunTime:0.014731s ]
  10. SELECT * FROM `fenlei` WHERE `id` = 66 LIMIT 1 [ RunTime:0.002476s ]
  11. SELECT * FROM `article` WHERE `id` < 522840 ORDER BY `id` DESC LIMIT 1 [ RunTime:0.013695s ]
  12. SELECT * FROM `article` WHERE `id` > 522840 ORDER BY `id` ASC LIMIT 1 [ RunTime:0.001117s ]
  13. SELECT * FROM `article` WHERE `id` < 522840 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.001612s ]
  14. SELECT * FROM `article` WHERE `id` < 522840 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.001611s ]
  15. SELECT * FROM `article` WHERE `id` < 522840 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.003414s ]
0.237572s