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专家知识库丨学术课件推荐:抗原特异性T细胞在重大疾病中的作用

  • 2026-08-22 00:55:33
专家知识库丨学术课件推荐:抗原特异性T细胞在重大疾病中的作用

医药行业研发周期长、技术壁垒高、信息不对称性显著等特点已是业内共识。优质创新成果长期依赖线下会议和点对点对接，传播受限、效率低下，大量具备临床价值与应用前景的技术方案未能得到充分的产业关注与资本响应。

为此，药未来APP正式推出 “专家知识库” 板块，为医药领域优质企业与个人专家搭建系统化、常态化的成果展示与资源对接平台，助力技术端与资本端、产业端的高效匹配。

专家知识库

学术课件推荐

抗原特异性T细胞在重大疾病中的作用

 王锋 

上海交通大学医学院/上海市免疫学研究所

研究员、课题组长、博士生导师

内容摘要与简介

OVERVIEW

本报告聚焦于肿瘤免疫与自身免疫疾病两大领域。报告以“第一性原理”为逻辑起点，指出T细胞受体（TCR）对抗原的精准识别是免疫系统能否有效清除肿瘤或失控攻击自身的根本前提。报告提出了“内外兼修”的解决思路——既要提升TCR对肿瘤新抗原的识别精度，也要增强T细胞在持续性抗原刺激下的功能持久性。

在肿瘤免疫部分，报告深入揭示了一条调控CD8+Ｔ细胞线粒体适应性与抗肿瘤持久性的关键信号轴。研究发现，某一在多种细胞中广泛表达的核蛋白，可作为转录因子的直接靶标，通过稳定线粒体DNA结合蛋白来维护电子传递链完整性，从而减少代谢应激下的活性氧损伤，有效延缓T细胞功能耗竭，为提升免疫检查点阻断疗法的持久疗效提供了新靶点。

在自身免疫疾病部分，报告聚焦于自身反应性CD4+Ｔ细胞异常迁移导致组织损伤的核心问题，阐明了一条由TCR信号强度驱动的转录调控级联反应。动物模型实验表明，阻断该信号轴可显著减轻多发性硬化、结肠炎及皮肤炎症等自身免疫病变。该报告贯通了分子机制与临床转化，为精准免疫干预提供了双重启示——在肿瘤中增强T细胞持久性，在自身免疫病中阻断致病性迁移。

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版权声明：

本期展示课件已通过药未来平台完成原创版权存证，受平台截屏下载限制。未经授权，禁止任何形式的转载、截屏或传播。

专家介绍

上海交通大学医学院/上海市免疫学研究所研究员、课题组长、博士生导师

国家万人计划青年拔尖人才

上海高校特聘教授(东方学者)

王锋博士长期致力于探索T细胞抗原识别和信号调节机制，以及抗原特异性T细胞在抗肿瘤、感染免疫和自身免疫疾病中的关键作用。以第/ 通讯F者身份在Nature Immunology, Immunity,Science Immunology，PNAS,EMBOJournal等国际知名期刊发表系列研究论文。申请国家/国际发明专利13项(其中6项已授权)，现联合上海交通大学医学院附属三甲医院开展免疫治疗相关临床试验。

入选国家万人计划青年拔尖人才，上海高校特聘教授(东方学者)，上海市青年拔尖人才，上海市浦江人才和曙光学者计划。研究获得包括国家自然科学基金重点项目，免疫力解码专项和国家重点研发计划在内的多个国家和省部级项目资助。担任中国生物医药产业链创新与转化联盟核酸药物分会副主委、免疫治疗药物分会秘书长，中国免疫学会青年工作委员会常委，中国药理学会呼吸药理专委会常委以及上海市免疫学会中医药免疫专委会副主委。

（下滑查看全部简介）

专家知识库

入驻·邀请

“专家知识库”板块现面向以下主体正式开放入驻通道：

在特定治疗领域或技术方向具有深厚积累的个人专家与学者

寻求融资、License-out、联合开发或战略合作的项目负责人

拥有成功转化经验或产业落地案例的资深行业顾问/专家

入驻后，相关展示内容将精准触达平台内的高净值用户群体，包括投资基金、跨国药企（MNC）、大型制药企业BD部门及其他潜在合作伙伴。

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  1. CONNECT:[ UseTime:0.000920s ] mysql:host=127.0.0.1;port=3306;dbname=a_sjds;charset=utf8mb4
  2. SHOW FULL COLUMNS FROM `fenlei` [ RunTime:0.001581s ]
  3. SELECT * FROM `fenlei` WHERE `fid` = 0 [ RunTime:0.000747s ]
  4. SELECT * FROM `fenlei` WHERE `fid` = 63 [ RunTime:0.000662s ]
  5. SHOW FULL COLUMNS FROM `set` [ RunTime:0.001369s ]
  6. SELECT * FROM `set` [ RunTime:0.000554s ]
  7. SHOW FULL COLUMNS FROM `article` [ RunTime:0.001573s ]
  8. SELECT * FROM `article` WHERE `id` = 524300 LIMIT 1 [ RunTime:0.018204s ]
  9. UPDATE `article` SET `lasttime` = 1787604784 WHERE `id` = 524300 [ RunTime:0.011030s ]
  10. SELECT * FROM `fenlei` WHERE `id` = 66 LIMIT 1 [ RunTime:0.000282s ]
  11. SELECT * FROM `article` WHERE `id` < 524300 ORDER BY `id` DESC LIMIT 1 [ RunTime:0.000507s ]
  12. SELECT * FROM `article` WHERE `id` > 524300 ORDER BY `id` ASC LIMIT 1 [ RunTime:0.000518s ]
  13. SELECT * FROM `article` WHERE `id` < 524300 ORDER BY `id` DESC LIMIT 10 [ RunTime:0.000653s ]
  14. SELECT * FROM `article` WHERE `id` < 524300 ORDER BY `id` DESC LIMIT 10,10 [ RunTime:0.001820s ]
  15. SELECT * FROM `article` WHERE `id` < 524300 ORDER BY `id` DESC LIMIT 20,10 [ RunTime:0.001097s ]
0.166627s